The life cycle of malaria is complicated and it involves two hosts – the human being and the mosquito. Once bitten by a female anopheles mosquito, the malarial parasite enters the blood stream. It travels all through his blood stream to reach the liver. In the liver the parasite matures and multiplies. Some of the parasites stay there whereas the other parasites move out from the liver attacking red blood cells. The parasite then multiplies in the red blood cells. In the next 48-72 hours, more parasites are released into the blood. This is the reason why the chills of malaria are generally seen after 48 to 72 hours corresponding to the release of the malarial parasite in the blood.